Cardiovascular genetics

Cardiovascular genetics: case studies.

Genetics of cardiovascular disease.

Fifty years ago, cardiovascular genetics simply did not exist. Genetics was a nascent field of basic research, with little apparent relevance to cardiovascular science or any other medical subspecialty. Today, cardiovascular genetics is a discipline that fully integrates high-technology laboratory investigation and clinical medicine. From this hybrid have emerged discoveries that have precisely...

Advances in Genetics Cardiovascular Epigenetics

Epigenetics is the study of heritable alterations in phenotypes and gene expression that occur without changes in the DNA sequence. Epigenetic mechanisms are flexible genomic factors that not only can change genome function under exogenous influence, but also can provide a molecular substrate that allows for the stable propagation of gene expression states from one generation of cells to the ne...

Genetics of Human Cardiovascular Disease

Cardiovascular disease encompasses a range of conditions extending from myocardial infarction to congenital heart disease, most of which are heritable. Enormous effort has been invested in understanding the genes and specific DNA sequence variants that are responsible for this heritability. Here, we review the lessons learned for monogenic and common, complex forms of cardiovascular disease. We...

Pneumoviruses: Molecular Genetics and Reverse Genetics

Pneumoviruses are responsible for significant respiratory disease in their hosts and represent a major problemfor human and animal health. Pneumoviruses are members of the family Paramyxoviridae, subfamilyPneumovirinae and the virus particles consist of a negative-sense, nonsegmented RNA genome within a helical nucleocapsid structure enveloped in a lipid membrane derived from the ho...